Abstract: Spline Subregion Method (SSM) is a new method of structural analysis on tall buidings. This paper is used by SSM to analyse structure of tall buildings and set up various SSM of tall tructures, and lead to calculation formulas of statics, dynamics, stabilities, geometrical non-linear, plasticultimate and interactions of structure, soil and foundations. The programme system is researched by SSM (Fortrain-4) and practices of calculations and engineerings proved very effective and economic. It is better than finite element and finite strip method.