Abstract: The performance and interaction between main structure and glass curtain wall under the individual and combined actions of wind and earthquake was studied. Glass curtain wall is added to a 98 m high frame-core wall according to the standard. Three groups of 3D data are selected from seismic records, and the wind pressure data of different return periods are obtained through a 1∶440 scale wind tunnel model test. Then the effects of individual and combined actions of wind and earthquake on the behavior of main structure and glass curtain wall are studied by the dynamic elastoplastic analysis method. The results show that main structure has a greater impact on glass curtain wall than on main structure. Whether under the individual or combined actions of wind and earthquake, the story drift of main structure was larger than glass wall itself. Under the design and super-intensity earthquake loadings, with the increase of the effective load, the response of the main structure and the damage degree of the glass curtain wall are increasing, and the growth of structural deformation are greater than base shear. Under wind load, glass curtain wall was not fail, main structure was in good stage, and the base shear, top displacement and max story drift increased linearly. Compared with rare earthquake acting alone, when 1.1 times 100-year return period wind pressure is combined, torsional effect appears, and story drift ratio increased from 1.0 to 1.3. The nonlinear effect of main structure and glass curtain wall is greater than the sum of wind and earthquake. The top displacement and the max story drift were 121% and 106% of the sum of wind and earthquake. Under rare earthquake or combined with wind pressure, the failure of glass curtain wall is more likely to happen on the side parallel to earthquake main direction.