Abstract: Microscale interfaces are included in macro-meso-micro multiscale analysis for progressive damage failure. Periodic boundary conditions are applied to the mesoscale and microscale cell model to obtain the amplification factors which are condensed by the k-means clustering method. The condensed amplification factors are used to obtain the stress of mesoscale and microscale components of macroscale models, and the damage failure judgement is conducted. The degraded elastic parameters of the macroscale model are calculated for subsequent calculation. The progressive damage failure analysis of 2D braided SiC/SiC composites is carried out. The correctness of the cluster number is verified by comparing the results calculated by using different cluster numbers. The results show that the material strength limits obtained by the simulation agreed well with the experimental results. The microscale interfaces cannot be ignored in multiscale analysis, or the material property will be greatly strengthened. The failure behavior of interfacial debonding and fiber bundle pullout of 2D braided SiC/SiC composites can be approximately characterized by this method.