Abstract: At present, the standing seam roof system with anti-wind clips is adopted in many largespan buildings to resist the action of strong wind. However, few further studies have been conducted on the changes in the deformation, stress and other characteristic responses of the standing seam roof system with anti-wind clips under wind loading. By means of experiment and numerical simulation, the influence of plate width, plate thickness, spacing between wind clips and other parameters on the characteristic response and bearing capacity of the roof system is studied. The failure criterion of the roof system is proposed and the formula for calculating the bearing capacity of the roof system is obtained by fitting. The research shows that the bearing capacity increases by about 10% for every 0.1 mm increase in plate thickness. The bearing capacity increases by 25% for every 100 mm reduction in plate width. When the anti-wind clips spacing is less than 1100 mm, the bearing capacity increases by about 20% for each reduction of 100 mm. When the anti-wind clips spacing is more than 1100 mm, the bearing capacity increases by about 10% for each reduction of 100 mm. Changing the structure of an anti-wind clip has little effect on the bearing capacity.