Abstract: For arsenal or dangerous goods warehouse, accidental explosion may happen. Since the warehouse is mainly made of reinforced concrete materials, it is therefore essential to study the failure process of reinforced concrete under explosive loading. In this study, based on the LS-DYNA software, the paper studies the dynamic failure process of reinforced concrete under explosive loading, which was investigated by using the Arbitrary Lagrange Euler (ALE) method and the multi-materials Fluid-Solid coupling method. In order to analyze the dynamic response of concrete structure under explosive load, strain rate dependent constitutive models were adopted for the rebar and concrete. In addition, zero thickness cohesive element was introduced to simulate the dynamic breakup process of concrete structure, which can overcome the mass loss problem caused by the erosion algorithm. In this paper, the generation process of the cohesive element model was firstly introduced. The developed model was then verified by comparing the numerical results with the experimental results. To demonstrate the superior capability of the proposed cohesive element model, the simulation results from the proposed model were compared with those obtained from erosion methods. Finally, based on the cohesive element models, the influence of different explosive loads on the dynamic failure process of concrete structure and the debris launching were analyzed.