Abstract: A finite element (FE) model for studying the fire performance of concrete filled steel tube (CFST) column-steel beam plane frames is proposed, and its results agree well with actual test results. Parameters such as fire location and the limits of its expansion, beam load, beam depth, strengthened beam ribs, and axial load level of columns were used to study the deformation and resulting internal force redistribution, the failure modes, the failure mechanism, and the fire resistance of CFST frames using the FE model. The results show that fire location and its expansion influence the fire resistance of CFST frames, and beam loading also has a great influence, while column axial load level has little influence.