Abstract: This study investigates the impact of non-stationarity in typhoon wind fields on the wind-induced response of high-rise buildings. The reverse order inspection method and round inspection method were employed to select nonstationary wind speed samples qualitatively based on the measured data from five landing typhoons. The standard deviation of a normalized local recurrence rate (SDNLRR) was used to quantitatively calculate the non-stationarity of wind speed samples. Based on the fluctuating wind speed samples with different non-stationarity levels, Hilbert-Wavelet Packet Decomposition method was used to reconstruct the wind field. The response of a CAARC typical high-rise building model which induced by the simulated wind loads was analyzed to explore how non-stationarity affects structural dynamic responses. The study results indicate that the wind speed samples from the eyewall's strong wind region exhibit significant non-stationary characteristics. As the SDNLRR increases from 0.301 to 0.903, the average vertex displacement, velocity and acceleration of the structure increase by 17.9%, 17.7% and 47.6%, respectively. The extreme responses under non-stationary wind speed samples are larger than that calculated by the load code for the design of building structures.