Abstract: Vehicle-pedestrian separated Double-deck bridge is one of the most important component of urban slow traffic systems. Its human-induced vibration (HiV) characteristics under crowd walking loads are still lack of investigation. Based on a self-anchored suspension bridge, this research firstly analyzed the dynamic properties of structure, which was inside the sensitive frequency range of typical HiV. Next, the matrix of random crowd walking loads was generated by Monte-Carlo Sampling. Through time-domain finite element analysis, the peak value and power spectra density (PSD) of structural acceleration responses were calculated and compared with the results of frequency method recommended by standard criteria as well. The research results show that time-domain analysis with consideration on the randomness between individual performs better. The vertical response features between upper and lower deck are similar, while the lateral response features show more difference. In details, the superior frequency of lower deck of lateral responses is gradually controlled by the vertical mode from mid-span to side-span. By comparing with current standard of pedestrian bridges for evaluating the comfort level, it is suggested that the randomness of crowd should be fully considered in the future.