Abstract: Upon the domain reduction idea, the FK-FE hybrid method is proposed to simulate the end-to-end structural seismic analysis by combing the merits of the semi-analytical frequency-wavenumber (FK) method and the finite element (FE) method. The FK approach, constructed by the exact dynamic stiffness matrix, can accurately and effectively simulate wave propagation in an 1D velocity structure. The finite element method can finely simulate seismic response of engineering structures due to its rich elements and constitutive.ABAQUS, a large-scale commercial finite element software, is secondarily developed by adding the FK code as a plug-in to reach the physical-based simulation of the end-to-end broadband seismic response. The FK-FE hybrid method is well verified and then applied to simulate the 0 Hz~15 Hz broadband seismic response of the 9-story Benchmark moment-resisting steel frame, designed by the American SAC, under the action of seismic dislocation. The influence of crustal velocity structure and site classes on the structural seismic response is discussed. The results show that the crustal velocity structure and the site classes significantly impact the structural displacement and the inter-story drift angle under the seismic dislocation. Compared with the case of soft crust (velocity structure 1), both the maximum structural displacement and the maximum inter-story drift angle are reduced by 22.7% and 62.0% in the hard crust (velocity structure 3), respectively. While for the case of site classes, those in site class Ⅱ are reduced by 22.3% and 44.7%, respectively, compared with the class Ⅳ.