Abstract: To investigate the complex soil-pile interaction of bridge piles foundation in the pit slope of a ship lock, as well as the influence of seepage, landslide thrust, lateral friction, the axial force effect and soil between piles and so on, the “m” method was applied to simulate pile-soil interaction. According to the force and moment balance condition, governing differential equation and second order accuracy differential equations of pile foundation were established. Finite difference method was employed to solve the differential equations and analyze the displacement and internal force of the foundation piles. The results of the study shows that the foundation pit excavation of ship lock has an adverse influence on the stability of bridge piles foundation in slope and the safety of bridge. Therefore, measures needs to be taken to reinforce the bridge pile foundations. The numerical analysis results show good agreement with monitoring data, proving the effectiveness of the theoretical analysis method. This method can be used as a reference to practical engineering design and research.