Abstract: A novel base seismic isolation-energy dissipative cladding panel (EDCP) hybrid control structure is proposed. In this structure, the lead rubber bearings (LRBs) are adopted as the base isolation devices, and EDCPs composed of cladding panels and U-shaped steel dampers (USDs) are arranged in the superstructure. This hybrid control method aims to realize the damage-free objective of main structure as well as non-structural cladding panels under the maximum considered earthquake, which can be used in important lifeline projects where high resilience is required. To compare the seismic performance of hybrid control structure and base isolation structure, a 1/2-scale reinforced concrete frame structure was designed and fabricated, which was exactly the same in the two directions. EDCPs were only equipped in the Y-direction, which led to a hybrid control structure; while it was a counterpart base isolation structure in the X-direction. Shaking table tests were conducted by inputting uniaxial ground motions in the two directions. The test results indicated that compared to the isolation control structure, the hybrid control structure can further reduce the displacement response of the superstructure under the design based and maximum considered earthquakes. The maximum inter-story drift of the hybrid control structure under the maximum considered earthquake was less than or close to the elastic inter-story drift limit of the reinforced concrete frame structure, and the main structure remained elastic and no damage occurred to the cladding panel, so that the desired performance objectives can be achieved.